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Replacement For |
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Poly Oxyl 40 Hydrogenated Castor Oil is replacement for Cremophor
RH40, Crysmer RH-40 and Tween 80.
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Typical Applications |
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Solubilizer: Poly Oxyl 40 Hydrogenated Castor Oil
improves water solubility of major water insoluble products.
Improves compatibility of incompatible ingredients.
Solubilizing
method for vitamis: Poly Oxyl 40 Hydrogenated Castor Oil is
almost odourless and tasteless. It ca be added to oral and topical
applications of vitamin A, D, E and K type form.
Formulation: Poly Oxyl 40 Hydrogenated Castor Oil is
almost odourless and tasteless. It ca be added to oral and topical
applications of vitamin A, D, E and K type form.
- Aqueous vitamin A palmitate solution (150 000 l.u/ml)
- Vitamin A palmitate : 1.7 million L.U/8.8g.
- Poly Oxyl 40 Hydrogenated Castor Oil : 25.0 g.
- Water : add 100 ml.
Mix vitamin with Poly Oxyl 40 Hydrogenated Castor Oil and heat
up to 600 to 650C. Heat water at the same temperature. With stirring
ad water in mixtue of Poly Oxyl 40 Hydrogenated Castor Oil and
vitamin. As a result of hydration, the viscosity will increase after
addition of around 50% water. Full addition of water will decrease
the viscosity up to required level. Quick addition of first 50%
water can make the formulation opalescent. Slow addition of water is
preffered. Solubilizing
of Pharma Ingrediants: Poly Oxyl 40 Hydrogenated Castor
Oilsolubilizes various hydrophobic substances in aqueous solutions
and make solutions clear.
Hexachlorocyclohexane |
Miconazole |
Hexedine |
Gramicidin |
Levomepromazine Thiopental |
Eucalyptol |
Benzocaine |
Oil of anise |
Clotrimazole Diazepam |
Oil of sage |
Foam Stabilizer: Poly Oxyl 40 Hydrogenated Castor Oil
has little tendency to foaming. But it works excellent when foaming
agents are added into the formulations. It works as foam booster and
foam stabilizer. Poly Oxyl 40 Hydrogenated Castor Oil is preferable
in shaving gel, hand wash gel, tooth paste and similar type of
cleaning and toiletories, formulations. To reduce or eliminate the
foam add small quantity of polypropylene glycol 2000 or simethecone.
Emulsifier : Poly Oxyl 40 Hydrogenated Castor Oil is
excellent versatile emulsifying agent. It will emulsify major
hydrophobic substances like fatty acids, fatty alcohols, mineral
oils.
Moisturizer: Poly Oxyl 40 Hydrogenated Castor Oil
improves moisturizing effect. It also improves soft feeling.
Film Former: Poly Oxyl 40 Hydrogenated Castor Oil
improves film foaming capability and flow properties. Poly
Oxyl 40 Hydrogenated Castor Oil is most preferred in Cream, Lotion,
Lipstick etc; to improve film forming.
Transparency Improvement: Poly Oxyl 40 Hydrogenated
Castor Oilsolubilize insoluble oily substances in aqueous system. It
improves transparency with shining. In cosmetic formulations,
impacting elegance appearance in cosmetic products such as shaving
gel, hair styling gel, hand wash gel. In Pharmaceutical syrup
formulations it improves transparency.
Volatility Retardment: Poly Oxyl 40 Hydrogenated Castor
Oil retards volatilities of volatile solvents. It can be used for
high volatile products like after shave perfumes to retain its
effect for longer period.
Masking Agent: Poly Oxyl 40 Hydrogenated Castor Oil
masks upleasant taste and odour of typical volatile solvents like
pharma syrup containing alcohols.
Adhesion Reducer: Poly Oxyl 40 Hydrogenated Castor Oil
reduces adhesion and chipping properties of oils. It gives smooth
feeling on application like in all pharma, cosmetic creams, and
lotions, hair oil, etc.
Aerosol Formulations: Poly Oxyl 40 Hydrogenated Castor
Oil improves solubility of the propellant in aerosols in aqueous
phase.
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Stability |
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Poly Oxyl 40 Hydrogenated Castor Oil is chemically highly stable
product. Prolonged exposure to heat can cause physical separation
into liquid and solid phase. At normal temperature it can be easily
restored to original form by homogenization.
Poly Oxyl 40 Hydrogenated Castor Oil is stable in aqueous solutions
and alcohol base aqueous solutions. Avoid use of strong bases and
acids in formulations with Poly Oxyl 40 Hydrogenated Castor Oil as
it may be Saponified.
Aqueous Poly Oxyl 40 Hydrogenated Castor Oil solutions can be
sterilized by heating up to 1200C. pH may decrease slightly. In case
of separation, slight agitation will remake the solution.
In aqueous solutions, add preservatives in requisite concentrations.
The concentration should be determined by test. Poly Oxyl 40
Hydrogenated Castor Oil is largely immune to the salts of hard
water.
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Compatibility |
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With skin and mucous membranes : Swab tests have demonstrated that
Poly Oxyl 40 Hydrogenated Castor Oil is compatible with human skin.
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Sensitization |
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Poly Oxyl 40 Hydrogenated Castor Oil solutions of 20% and 50%
concentration in acetone were brushed ten times on the skin of
guinea pigs. They did not cause any sensitization of the skin.
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Toxicity |
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Acute and chronic toxicity test in animals have shown Poly Oxyl 40
Hydrogenated Castor Oil is essentially non-toxic and non-irritant
material.
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Shelf Life |
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Acute and chronic toxicity test in animals have shown Poly Oxyl 40
Hydrogenated Castor Oil is essentially non-toxic and non-irritant
material.
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Packing |
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5 kgs., 20 kgs., & 50 kgs., in Plastic Carboys. |