 |
Water
Soluble Carbomer Fo Thickening, Suspending & Stabilizing
 |
Description
|
 |
CARBOMER range are synthetic high molecular weight crosslinked polymers
of acrylic acid, which confirm to USP./INF. specifications as "CARBOMER"
|
Use |
|
CARBOMER range, are water soluble
polymer use to :
| Thicken |
To produce wide range
of viscosities and flow properties. |
| Suspend |
Insoluble
ingredients. |
| Stabilize &
Emulsify |
Emulsions |
|
Grade
& Applications |
|
| Grades |
Solvent used in process |
Carbomer 934P / 974P
(Benzene
free) |
Benzene
Cyclohexane
& ethyl acetate |
Carbomer 934P / 974P - High
purity oral pharmaceutical grade for formulations.
Gel, Lotion and ointment.
Oral liquid, suspension and emulsion. Sustained
release formulation by matrix system.
Opthalmic gel and eye - lotion.
Transdermal (skin) drug delivery.
Taste masking.
 |
|
Advantages |
|
| Thickning efficiency |
High viscosities
at low concentrations. |
| Uniform performance |
Reproducibility
unattainable with natural gums. |
| Safety |
Years of
successful use of carbomers. |
| Temperature stability |
Extended up to 750C
heating or cooling |
| Unaffected by aging |
Excellent self
life. |
| Microbial resistance |
Resists bacterial
attack and does not support mold growth |
| Versatility |
Although
primarily used in aqueous systems with neutralization. It can
also be used in solvent systems, with or without neutralization.
|
| Elegance |
Smooth and
luxurious feeling. |
|
Chilling Properties |
|
On refrigeration CARBOMER gel can retaining the cool temperature
level for 48 hours to 72 hours.
Low temperature necessary for vaccines, toxoids, insulin and human
albumin can be store in pre-refrigerated CARBOMER gel, making it as
a suitable medium for transporting these medicines.
|
Specifications |
|
| Appearance |
White fine free
flowing powder. |
| Odour |
Mild acidic. |
| pH of 1% solution |
2.5 to 3 |
| Carboxylic content |
56% to 68% |
| Heavy metals |
Max. 2 ppm |
| Temperature stability |
Up to 75°C |
|
Grades |
|
| Grades |
Viscosity (20°C, 0.5% Neutralization) |
| Carbomer 934P /
974P |
29,400 - 39,400
cps. |
|
Preparation of Aqueous Transparent Gel |
|
| D.M. water |
97.0 gm. |
| Carbomer (Any Grade) |
0.5 gm. |
Sodium Hyroxide
(10% solution)
|
2.5 gm. |
|
Neutralizers Recommended |
|
| Sodium Hydroxide |
Potassium
Hydroxide |
| Triethanol Amine |
Triethyl amine,
other alkalies etc.. |
|
Toxicity |
|
CARBOMER is a high molecular weight polymer. It is not absorbed by
body tissues and is totally safe for human oral consumption. Test
for toxicological tolerance show that it does not have pronounced
physiological action and is non toxic.
|
Storage |
|
Store in cool dry place. Keep away from moisture and water.
|
Packing |
|
5 kg., 20 kg., net in corrugated box.
|
Certificate of Analysis ( CARBOMER - 974P ) |
|
| No. |
Test |
Specification |
Results |
| 1 |
Description |
White Free Flowing Powder |
White Free Flowing Powder |
| 2 |
Solubility |
Complies |
Alkali Water |
| 3 |
Identification |
A. Complies
B. Complies |
Complies |
| 4 |
Viscosity
(0.5%
Solution) |
Bet'n 29400 To 39400 Cps |
36200 Cps |
| 5 |
Loss on Drying |
NMT 2.0% |
1.2% |
| 6 |
Heavy Metals |
NMT 0.002% |
Complies |
| 7 |
Assay For Carboxylic Acid
Content |
Bet'n 56.0% To 68.0% |
59.8% |
|
Certificate of Analysis ( CARBOMER - 934P ) |
|
| No. |
Test |
Specification |
Results |
| 1 |
Description |
White Free Flowing Powder |
White Free Flowing Powder |
| 2 |
Solubility |
Complies |
Alkali Water |
| 3 |
Identification |
A. Complies
B. Complies |
Complies |
| 4 |
Viscosity
(0.5%
Solution) |
Bet'n 29400 To 39400 Cps |
38850 Cps |
| 5 |
Loss on Drying |
NMT 2.0% |
0.9% |
| 6 |
Heavy Metals |
NMT 0.002% |
Complies |
| 7 |
Limit Of Benzene (By Gc) |
NMT 0.01% |
0.0021% |
| 8 |
Organic Volatile Impurities |
Complies |
Complies |
| 9 |
Assay For Carboxylic Acid
Content |
Bet'n 56.0% To 68.0% |
59.9% |
|
|
 |
